New Cochrane Neonatal review: Non-invasive respiratory support for the management of transient tachypnea of the newborn.
#cochrane #newborn #pulmonology #tachypnoea
#cochrane #newborn #pulmonology #tachypnoea
👉Time to Say Goodbye to Bronchiolitis, Viral Wheeze, Reactive Airways Disease, Wheeze Bronchitis and All That
📌A proposed simplified approach to the nomenclature used to categorize virus associated LRTIs is presented based on an understanding of the underlying pathological processes and how these contribute to the physical signs.
🔗https://www.frontiersin.org/articles/10.3389/fped.2020.00218/full
👉open access
#pulmonology #infections #orvi #bronchitis #resparatory #frontiersin
📌A proposed simplified approach to the nomenclature used to categorize virus associated LRTIs is presented based on an understanding of the underlying pathological processes and how these contribute to the physical signs.
🔗https://www.frontiersin.org/articles/10.3389/fped.2020.00218/full
👉open access
#pulmonology #infections #orvi #bronchitis #resparatory #frontiersin
👉Biomarkers and Disease Severity in Children With Community-Acquired Pneumonia
📌WBC count, ANC, CRP, and procalcitonin are generally not useful to discriminate nonsevere from severe disease in children with CAP, although CRP and procalcitonin may have some utility in predicting the most severe outcomes.
🔗https://pediatrics.aappublications.org/content/145/6/e20193728
#pneumonia #crp #pct #respiration #aap #pulmonology #infections #pediatrics
📌WBC count, ANC, CRP, and procalcitonin are generally not useful to discriminate nonsevere from severe disease in children with CAP, although CRP and procalcitonin may have some utility in predicting the most severe outcomes.
🔗https://pediatrics.aappublications.org/content/145/6/e20193728
#pneumonia #crp #pct #respiration #aap #pulmonology #infections #pediatrics
👉Typical RSV cough: myth or reality? A diagnostic accuracy study
📌Respiratory syncytial virus (RSV) is well known for causing a potentially severe course of bronchiolitis in infants. Many paediatric healthcare workers claim to be able to diagnose RSV based on cough sound, which was evaluated in this study. Parents of children < 1 year old admitted to the paediatric ward because of airway complaints were asked to record cough sounds of their child. In all children, MLPA analysis—a variation of PCR analysis—on nasopharyngeal swab was performed (golden standard). Sixteen cough fragments representing 4 different viral pathogens were selected and presented to paediatric healthcare workers. Thirty-two paediatric nurses, 16 residents and 16 senior staff members were asked to classify the audio files and state whether the cough was due to RSV infection or not. Senior staff, nurses and residents correctly identified RSV with a sensitivity of 76.2%, 73.1% and 51.3% respectively. Correct exclusion of RSV cases was performed with a specificity of 60.8%, 60.2% and 65.3% respectively. Sensitivity ranged from 0 to 100% between colleagues; no one correctly identified all negatives. Residents had significantly lower rates of sensitivity than senior staff and nurses. This was strongly related to work experience, in which more than 3.5 years of work experience was related to the best result.
🔗https://link.springer.com/article/10.1007%2Fs00431-020-03709-1
#cough #rsv #infections #pulmonology #springer
📌Respiratory syncytial virus (RSV) is well known for causing a potentially severe course of bronchiolitis in infants. Many paediatric healthcare workers claim to be able to diagnose RSV based on cough sound, which was evaluated in this study. Parents of children < 1 year old admitted to the paediatric ward because of airway complaints were asked to record cough sounds of their child. In all children, MLPA analysis—a variation of PCR analysis—on nasopharyngeal swab was performed (golden standard). Sixteen cough fragments representing 4 different viral pathogens were selected and presented to paediatric healthcare workers. Thirty-two paediatric nurses, 16 residents and 16 senior staff members were asked to classify the audio files and state whether the cough was due to RSV infection or not. Senior staff, nurses and residents correctly identified RSV with a sensitivity of 76.2%, 73.1% and 51.3% respectively. Correct exclusion of RSV cases was performed with a specificity of 60.8%, 60.2% and 65.3% respectively. Sensitivity ranged from 0 to 100% between colleagues; no one correctly identified all negatives. Residents had significantly lower rates of sensitivity than senior staff and nurses. This was strongly related to work experience, in which more than 3.5 years of work experience was related to the best result.
🔗https://link.springer.com/article/10.1007%2Fs00431-020-03709-1
#cough #rsv #infections #pulmonology #springer
👉Synthetic Surfactant CHF5633 compared with Poractant Alfa in the Treatment of Neonatal Respiratory Distress Syndrome: A Multicenter, Double Blind, Randomized, Controlled Clinical Trial
📌Treatment with CHF5633 showed similar efficacy and safety as PA in preterm neonates with moderate to severe RDS.
🔗https://www.jpeds.com/article/S0022-3476(20)30725-3/fulltext
#surfactant #rds #pulmonology #jpeds
📌Treatment with CHF5633 showed similar efficacy and safety as PA in preterm neonates with moderate to severe RDS.
🔗https://www.jpeds.com/article/S0022-3476(20)30725-3/fulltext
#surfactant #rds #pulmonology #jpeds
👉A randomized controlled trial of restricted versus standard fluid management in late preterm and term infants with transient tachypnea of the newborn
📌This trial demonstrated the safety and effectiveness of restrictive fluid strategy in reducing CPAP duration in late preterm and term babies with TTNB. Late preterm babies, especially those not exposed to antenatal steroid were the most benefitted by this strategy.
🔗https://pubmed.ncbi.nlm.nih.gov/32444567/
#ttn #respiration #pulmonology #tachypnea
📌This trial demonstrated the safety and effectiveness of restrictive fluid strategy in reducing CPAP duration in late preterm and term babies with TTNB. Late preterm babies, especially those not exposed to antenatal steroid were the most benefitted by this strategy.
🔗https://pubmed.ncbi.nlm.nih.gov/32444567/
#ttn #respiration #pulmonology #tachypnea
👉Fate of pulmonary hypertension associated with bronchopulmonary dysplasia beyond 36 weeks postmenstrual age
📌These extremely preterm born infants with PH-BPD had a survival rate of 58% at 6 months corrected age. Suprasystemic pulmonary artery pressure was associated with poor outcome. In the current study, infants surviving beyond the corrected age of 6 months showed excellent survival and resolution of PH in almost all cases. Prospective follow-up studies should investigate whether resolution of PH in these infants can be improved by multi-modal therapies, including respiratory, nutritional and cardiovascular treatments.
🔗https://doi.org/10.1136/archdischild-2019-318531
#bld #hypertension #pulmonary #pulmonology
📌These extremely preterm born infants with PH-BPD had a survival rate of 58% at 6 months corrected age. Suprasystemic pulmonary artery pressure was associated with poor outcome. In the current study, infants surviving beyond the corrected age of 6 months showed excellent survival and resolution of PH in almost all cases. Prospective follow-up studies should investigate whether resolution of PH in these infants can be improved by multi-modal therapies, including respiratory, nutritional and cardiovascular treatments.
🔗https://doi.org/10.1136/archdischild-2019-318531
#bld #hypertension #pulmonary #pulmonology