👉Influence of time under mechanical ventilation on bronchopulmonary dysplasia severity in extremely preterm infants: a pilot study

📌Time under MV related to moderate to severe BPD development is 36 days, and worst outcomes are related to disease severity. PH and time under MV for more than 36 days are related to development of moderate to severe BPD.

🔗https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-020-02129-2

#respiration #bld #preterm #bmj #ventilation

👉#Lung recruitment before surfactant administration in extremely preterm neonates with respiratory distress syndrome (IN-REC-SUR-E): a randomised, unblinded, controlled trial

📌Lung recruitment before surfactant (IN-REC-SURE) ~open lung #ventilation compared to #INSURE reduces need for mechanical ventilation without increasing harm (pneumo/IVH/mortality) in <28 w Prems.

🔗https://doi.org/10.1016/S2213-2600(20)30179-X

#respiratory #respiration

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👉Positive End-Expiratory Pressure in Newborn Resuscitation Around Term: A Randomized Controlled Trial

📌We found no evidence for improved heart rate response during bag-mask #ventilation with PEEP compared with no PEEP. The #PEEP valve delivered a median PEEP within the intended range. The findings do not support routine use of PEEP during #resuscitation of newborns around term.

🔗https://doi.org/10.1542/peds.2020-0494

Compared with NCPAP, bi-level noninvasive #ventilation (nsNIPPV and SNIPPV) in premature infants with RDS resulted in less re-intubation and BPD. Also, nsNIPPV resulted in less intubation versus #NCPAP, with no difference in mortality.

https://doi.org/10.1159/000514637
*The full text is in the comments

Can we do better in (i) identifying those very immature preterm infants best equipped for noninvasive stabilization, can we improve (ii) determinants of failure of noninvasive respiratory support in the individual infant and underlying etiology, and can we enhance (iii) success of #noninvasive respiratory support and (iv) better prevent ultimate harm to the developing lung?

#NCPAP #ventilation
doi.org/10.1159/000515818
*The full text is in the comments

Based on DAM device information and reported literature, there are three modern options for #DAM in neonates and infants that can be selected according to the anatomical difficulty and device-oriented strategy.

#ventilation #airways
doi.org/10.3389/fped.2021.654291
*The full text is in the comments