👉Evaluation for Neonatal HSV in Infants Undergoing Workup for Serious Bacterial Infection: A 5-Year Retrospective Review
📌Neonatal herpes simplex virus (HSV) infection carries a high risk of mortality and, among survivors, morbidity, including developmental delay and seizures. Accurate and timely diagnosis, which is necessary to reduce mortality, is complicated by the range of clinical presentations, which can include few or no signs, symptoms, or characteristic laboratory findings. Although diagnosis in infants with skin-eye-mucosal (SEM) disease may be immediately apparent on the basis of the presence of vesicles,9 other manifestations of HSV may be more difficult to identify. Infants with disseminated disease, for example, can present with fulminant sepsis and disseminated intravascular coagulation or simply with hypothermia and lethargy.Similarly, infants with isolated central nervous system (CNS) HSV can present with few nonspecific clinical and laboratory findings, especially early in the disease.
🔗https://hosppeds.aappublications.org/content/early/2020/05/07/hpeds.2020-0033
👉open access
#herpes #infections #aap #pediatricshospital #neonatology
📌Neonatal herpes simplex virus (HSV) infection carries a high risk of mortality and, among survivors, morbidity, including developmental delay and seizures. Accurate and timely diagnosis, which is necessary to reduce mortality, is complicated by the range of clinical presentations, which can include few or no signs, symptoms, or characteristic laboratory findings. Although diagnosis in infants with skin-eye-mucosal (SEM) disease may be immediately apparent on the basis of the presence of vesicles,9 other manifestations of HSV may be more difficult to identify. Infants with disseminated disease, for example, can present with fulminant sepsis and disseminated intravascular coagulation or simply with hypothermia and lethargy.Similarly, infants with isolated central nervous system (CNS) HSV can present with few nonspecific clinical and laboratory findings, especially early in the disease.
🔗https://hosppeds.aappublications.org/content/early/2020/05/07/hpeds.2020-0033
👉open access
#herpes #infections #aap #pediatricshospital #neonatology