А у последнего выпуска Science очень интересная тематика: Genes & Environment.
Вот некоторые обзоры:
- A review of recent human adaptation (http://science.sciencemag.org/content/354/6308/54)
- Models and mechanisms of non–DNA sequence–based inheritance (http://science.sciencemag.org/content/354/6308/59)
- Genomic dissection of the effect of cellular environment on immune response (http://science.sciencemag.org/content/354/6308/64)
Вот некоторые обзоры:
- A review of recent human adaptation (http://science.sciencemag.org/content/354/6308/54)
- Models and mechanisms of non–DNA sequence–based inheritance (http://science.sciencemag.org/content/354/6308/59)
- Genomic dissection of the effect of cellular environment on immune response (http://science.sciencemag.org/content/354/6308/64)
Science
Going global by adapting local: A review of recent human adaptation
The spread of modern humans across the globe has led to genetic adaptations to diverse local environments. Recent developments in genomic technologies, statistical analyses, and expanded sampled populations have led to improved identification and fine-mapping…
Статья в Nature от DeepMind:
- http://www.nature.com/nature/journal/vaop/ncurrent/full/nature20101.html
- https://deepmind.com/blog/differentiable-neural-computers/
- https://news.ycombinator.com/item?id=12694779
- https://news.ycombinator.com/item?id=12698872
- http://www.readcube.com/articles/10.1038/nature20101?shared_access_token=3UerOr1f0fy3oL_CytWdxtRgN0jAjWel9jnR3ZoTv0MggmpDmwljGswxVdeocYSujsARxGW1q2qxK0cTqi1Bup-nSH200cGUW_ET9MIG_6rvvXTcoxOnAX6B4E8dQs4FQ-yScxXe8EB0XnzqbUw3Qw%3D%3D
- http://www.nature.com/nature/journal/vaop/ncurrent/full/nature20101.html
- https://deepmind.com/blog/differentiable-neural-computers/
- https://news.ycombinator.com/item?id=12694779
- https://news.ycombinator.com/item?id=12698872
- http://www.readcube.com/articles/10.1038/nature20101?shared_access_token=3UerOr1f0fy3oL_CytWdxtRgN0jAjWel9jnR3ZoTv0MggmpDmwljGswxVdeocYSujsARxGW1q2qxK0cTqi1Bup-nSH200cGUW_ET9MIG_6rvvXTcoxOnAX6B4E8dQs4FQ-yScxXe8EB0XnzqbUw3Qw%3D%3D
Deepmind
Differentiable neural computers
In a recent study in Nature, we introduce a form of memory-augmented neural network called a differentiable neural computer, and show that it can learn to use its memory to answer questions about complex, structured data, including artificially generated…
23andMe не стали делать ставку на NGS: https://www.buzzfeed.com/stephaniemlee/23andme-anne-wojcicki-next-generation-sequencing
BuzzFeed
23andMe Has Abandoned The Genetic Testing Tech Its Competition Is Banking On
Genetics startup 23andMe has let go of a team of scientists and a top executive as it has stopped pursuing one of the biggest technological advancements in DNA testing, BuzzFeed News has learned.
Интересная история «Brain implants allow paralysed monkeys to walk» и, как всегда, интересное обсуждение:
- http://www.nature.com/news/brain-implants-allow-paralysed-monkeys-to-walk-1.20967
- https://www.reddit.com/r/science/comments/5c2ljz/brain_implant_device_enables_paralyzed_monkeys/d9trzrr/
- https://news.ycombinator.com/item?id=12930811
- http://www.nature.com/news/brain-implants-allow-paralysed-monkeys-to-walk-1.20967
- https://www.reddit.com/r/science/comments/5c2ljz/brain_implant_device_enables_paralyzed_monkeys/d9trzrr/
- https://news.ycombinator.com/item?id=12930811
Nature
Brain implants allow paralysed monkeys to walk
Nature - Swiss researchers travel to China to conduct pioneering experiment.
Про лингвистические структуры в Nature Neuroscience.
http://www.nature.com/neuro/journal/v19/n1/full/nn.4186.html
http://www.nature.com/neuro/journal/v19/n1/full/nn.4186.html
О том, что с гендерной идентификацией у воробьёв всё сложно.
http://www.nature.com/news/the-sparrow-with-four-sexes-1.21018
http://www.nature.com/news/the-sparrow-with-four-sexes-1.21018
Nature News & Comment
The sparrow with four sexes
Elaina Tuttle spent her life trying to understand the bizarre chromosome evolution of a common bird — until tragedy struck.
http://biorxiv.org/content/early/2016/08/02/055541
Название захватывающее:
A reference dataset of 5.4 million phased human variants validated by genetic inheritance from sequencing a three-generation 17-member pedigree
Название захватывающее:
A reference dataset of 5.4 million phased human variants validated by genetic inheritance from sequencing a three-generation 17-member pedigree
bioRxiv
A reference dataset of 5.4 million phased human variants validated by genetic inheritance from sequencing a three-generation 17…
Improvement of variant calling in next-generation sequence data requires a comprehensive, genome-wide catalogue of high-confidence variants called in a set of genomes for use as a benchmark. We generated deep, whole-genome sequence data of seventeen individuals…
Отличная небольшая подборка про то, какие яды животных используются в качестве лекарств. Побольше бы подобных материалов!
https://mosaicscience.com/extra/medical-menagerie-gallery-venomous-creatures
https://mosaicscience.com/extra/medical-menagerie-gallery-venomous-creatures
Wellcome
Mosaic has now closed | Wellcome
Wellcome's digital platform dedicated to long-form journalism about science and health, has now closed.
Очаровательно: сказки, которые вдохновляют заниматься наукой. От редакторов Nature.
http://www.nature.com/nature/journal/v540/n7632/full/540194a.html
(А вот перевод на русский большинства из этих книг, кажется, отсутствует.)
http://www.nature.com/nature/journal/v540/n7632/full/540194a.html
(А вот перевод на русский большинства из этих книг, кажется, отсутствует.)
Nature
Tales of wonder : Nature : Nature Research
A bedtime story can ignite a lifelong love of science. Nature editors riffle through shelves and memories for favourites old and new.
Динозавр в янтаре (http://www.cell.com/current-biology/fulltext/S0960-9822(16)31193-9), использование нейроглобина как антидота при отравлении угарным газом (http://stm.sciencemag.org/content/8/368/368ra173) и обучение у животных (http://www.nature.com/articles/srep38427).
Кстати, интересное из Nature Biotechnology:
- Анализ изображений в биологии (http://www.nature.com/nbt/journal/v34/n12/abs/nbt.3722.html)
- Поправка на систематические ошибки при оценке представленности транскрипта в образце (http://www.nature.com/nbt/journal/v34/n12/abs/nbt.3682.html)
- Изучение длинных некодирующих РНК через их вырезание из генома с помощью CRISPR-Cas9 (http://www.nature.com/nbt/journal/v34/n12/abs/nbt.3715.html)
- Single-cell транскриптом малых РНК (http://www.nature.com/nbt/journal/v34/n12/abs/nbt.3701.html)
- Анализ изображений в биологии (http://www.nature.com/nbt/journal/v34/n12/abs/nbt.3722.html)
- Поправка на систематические ошибки при оценке представленности транскрипта в образце (http://www.nature.com/nbt/journal/v34/n12/abs/nbt.3682.html)
- Изучение длинных некодирующих РНК через их вырезание из генома с помощью CRISPR-Cas9 (http://www.nature.com/nbt/journal/v34/n12/abs/nbt.3715.html)
- Single-cell транскриптом малых РНК (http://www.nature.com/nbt/journal/v34/n12/abs/nbt.3701.html)
Nature
Imagining the future of bioimage analysis : Nature Biotechnology : Nature Research
Modern biological research increasingly relies on image data as a primary source of information in unraveling the cellular and molecular mechanisms of life. The quantity and complexity of the data generated by state-of-the-art microscopes preclude visual…
10 важных людей уходящего года по версии Nature.
http://www.nature.com/news/nature-s-10-1.21157
http://www.nature.com/news/nature-s-10-1.21157
Nature News & Comment
Nature’s 10
Ten people who mattered this year.
Про генетику эскимосов, живущих в Гренландии (оригинал в Molecular Biology and Evolution http://mbe.oxfordjournals.org/content/early/2016/12/20/molbev.msw283.full.pdf, краткий обзор в The Verge http://www.theverge.com/2016/12/31/12829094/inuit-greenland-denisovan-genome-cold-brown-fat).
Ставшая классической история про высотные адаптации (статья в Science http://science.sciencemag.org/content/329/5987/72, обзорные статьи на Чердаке http://chrdk.ru/sci/high_altitude и в Science http://www.sciencemag.org/news/2014/07/tibetans-inherited-high-altitude-gene-ancient-human).
Ставшая классической история про высотные адаптации (статья в Science http://science.sciencemag.org/content/329/5987/72, обзорные статьи на Чердаке http://chrdk.ru/sci/high_altitude и в Science http://www.sciencemag.org/news/2014/07/tibetans-inherited-high-altitude-gene-ancient-human).
Подборка про хроматин и эпигенетику.
- Лонгрид в The New Yorker: http://www.newyorker.com/magazine/2016/05/02/breakthroughs-in-epigenetics
- Иллюстрация достижений в эпигенетике от Scientific American: https://blogs.scientificamerican.com/sa-visual/gene-regulation-illustrated/
- Specification and epigenetic programming of the human germ line http://www.nature.com/nrg/journal/v17/n10/full/nrg.2016.88.html
- The detailed 3D multi-loop aggregate/rosette chromatin architecture and functional dynamic organization of the human and mouse genomes https://epigeneticsandchromatin.biomedcentral.com/articles/10.1186/s13072-016-0089-x
- Targeted degradation of CTCF decouples local insulation of chromosome domains from higher‐order genomic compartmentalization http://biorxiv.org/content/biorxiv/early/2016/12/21/095802.full.pdf
#chromatin #epigenetics
- Лонгрид в The New Yorker: http://www.newyorker.com/magazine/2016/05/02/breakthroughs-in-epigenetics
- Иллюстрация достижений в эпигенетике от Scientific American: https://blogs.scientificamerican.com/sa-visual/gene-regulation-illustrated/
- Specification and epigenetic programming of the human germ line http://www.nature.com/nrg/journal/v17/n10/full/nrg.2016.88.html
- The detailed 3D multi-loop aggregate/rosette chromatin architecture and functional dynamic organization of the human and mouse genomes https://epigeneticsandchromatin.biomedcentral.com/articles/10.1186/s13072-016-0089-x
- Targeted degradation of CTCF decouples local insulation of chromosome domains from higher‐order genomic compartmentalization http://biorxiv.org/content/biorxiv/early/2016/12/21/095802.full.pdf
#chromatin #epigenetics
The New Yorker
Same but Different
How the field of epigenetics complicates the nature-versus-nurture debate.
Подборка про длинные некодирующие РНК.
- Pan-Cancer Analyses Reveal Long Intergenic Non-Coding RNAs Relevant to Tumor Diagnosis, Subtyping and Prognosis http://www.sciencedirect.com/science/article/pii/S2352396416301104
- Distinctive Patterns of Transcription and RNA Processing for Human lincRNAs http://www.sciencedirect.com/science/article/pii/S1097276516307742
- Long noncoding RNAs inthe p53 network http://onlinelibrary.wiley.com/wol1/doi/10.1002/wrna.1410/full
- NEAT1 is Required for Survival of Breast Cancer Cells Through FUS and miR-548 http://www.la-press.com/neat1-is-required-for-survival-of-breast-cancer-cells-through-fus-and--article-a5561
- High expression of long non-coding RNA SBF2-AS1 promotes proliferation in non-small cell lung cancer http://jeccr.biomedcentral.com/articles/10.1186/s13046-016-0352-9
- Long Non-coding RNAs in the Cytoplasm (Review) http://www.sciencedirect.com/science/article/pii/S1672022916300377
- Evolution to the rescue: using comparative genomics to understand long non-coding RNAs (Review) http://www.nature.com/nrg/journal/v17/n10/full/nrg.2016.85.html
- Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer http://www.nature.com/ng/journal/v48/n10/full/ng.3637.html
- Local regulation of gene expression by lncRNA promoters, transcription and splicing http://www.nature.com/nature/journal/v539/n7629/full/nature20149.html
- Neighboring Gene Regulation by Antisense Long Non-Coding RNAs http://www.mdpi.com/1422-0067/16/2/3251
- Unusual Processing Generates SPA LncRNAs that Sequester Multiple RNA Binding Proteins http://www.cell.com/molecular-cell/pdfExtended/S1097-2765(16)30630-X
#lncRNAs
- Pan-Cancer Analyses Reveal Long Intergenic Non-Coding RNAs Relevant to Tumor Diagnosis, Subtyping and Prognosis http://www.sciencedirect.com/science/article/pii/S2352396416301104
- Distinctive Patterns of Transcription and RNA Processing for Human lincRNAs http://www.sciencedirect.com/science/article/pii/S1097276516307742
- Long noncoding RNAs inthe p53 network http://onlinelibrary.wiley.com/wol1/doi/10.1002/wrna.1410/full
- NEAT1 is Required for Survival of Breast Cancer Cells Through FUS and miR-548 http://www.la-press.com/neat1-is-required-for-survival-of-breast-cancer-cells-through-fus-and--article-a5561
- High expression of long non-coding RNA SBF2-AS1 promotes proliferation in non-small cell lung cancer http://jeccr.biomedcentral.com/articles/10.1186/s13046-016-0352-9
- Long Non-coding RNAs in the Cytoplasm (Review) http://www.sciencedirect.com/science/article/pii/S1672022916300377
- Evolution to the rescue: using comparative genomics to understand long non-coding RNAs (Review) http://www.nature.com/nrg/journal/v17/n10/full/nrg.2016.85.html
- Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer http://www.nature.com/ng/journal/v48/n10/full/ng.3637.html
- Local regulation of gene expression by lncRNA promoters, transcription and splicing http://www.nature.com/nature/journal/v539/n7629/full/nature20149.html
- Neighboring Gene Regulation by Antisense Long Non-Coding RNAs http://www.mdpi.com/1422-0067/16/2/3251
- Unusual Processing Generates SPA LncRNAs that Sequester Multiple RNA Binding Proteins http://www.cell.com/molecular-cell/pdfExtended/S1097-2765(16)30630-X
#lncRNAs
La-Press
NEAT1 is Required for Survival of Breast Cancer Cells Through FUS and
NEAT1 is Required for Survival of Breast Cancer Cells Through FUS and miR-548
Подборка материалов на разные темы.
Про ингибиторы деацетилаз.
Quartz: «Scientists have created a drug that replicates the health benefits of exercise» (http://qz.com/783958/scientists-have-created-a-drug-that-replicates-the-health-benefits-of-exercise/)
Original article: «Disruption of the Class IIa HDAC Corepressor
Complex Increases Energy Expenditure and Lipid
Oxidation» (http://www.cell.com/cell-reports/pdf/S2211-1247(16)31051-8.pdf)
Про текущее состояние данных, выкладываемых в публичный доступ.
«Gene name errors are widespread in the scientific literature» (http://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-1044-7)
На самом деле, смешного в этом мало.
Про рак и старение.
«Analysis of cancer genomes reveals basic features of human aging and its role in cancer development» (http://www.nature.com/articles/ncomms12157)
Про codon usage.
«Codon optimality controls differential mRNA translation
during amino acid starvation» (http://rnajournal.cshlp.org/content/early/2016/09/09/rna.058180.116.full.pdf)
«Evolutionary switches between two serine codon sets
are driven by selection» (http://www.pnas.org/content/113/46/13109.full.pdf?with-ds=yes)
Теория эволюции геномов прокариот от Кунина.
«Theory of prokaryotic genome evolution» (http://www.pnas.org/content/113/41/11399.full)
Про антитела против HIV.
The Verge: «One patient’s blood might hold a new weapon against HIV» (http://www.theverge.com/2016/11/17/13670948/hiv-treatment-drug-vaccine-antibodies-neutralizing-blocking)
Original article: «Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth» (http://www.cell.com/immunity/fulltext/S1074-7613(16)30438-1)
Про рибо-переключатели.
«Cotranscriptional folding of a riboswitch at nucleotide resolution» (http://www.nature.com/nsmb/journal/v23/n12/full/nsmb.3316.html)
Про то, как в научных группах используют Slack или MatterMost.
«How scientists use Slack» (http://www.nature.com/news/how-scientists-use-slack-1.21228)
Про Булгакова.
«Maestro, Marguerite, morphine: The last years in the life of Mikhail Bulgakov» (http://www.sciencedirect.com/science/article/pii/S1874391915301743)
Очень странная статья-эссе.
«A Speculative History of DNA: What If Oswald Avery Had Died in 1934?» (http://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.2001197&type=printable)
Обзорная статья про фаговую терапию.
Оригинал на Nautilus: «Will Viruses Save Us From Superbugs?» (http://nautil.us/issue/43/heroes/will-viruses-save-us-from-superbugs)
Перевод на Geektimes: «Спасут ли нас вирусы от супербактерий?»
(https://geektimes.ru/post/283744/)
Про генетику пола.
«Why Sex Is Mostly Binary but Gender Is a Spectrum» (http://nautil.us/issue/43/heroes/why-sex-is-binary-but-gender-is-a-spectrum)
Про неаннотированные splice junctions.
«Human splicing diversity and the extent of unannotated splice junctions across human RNA-seq samples on the Sequence Read Archive» (http://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-1118-6)
Web Collection от Nature: Computational Biology.
http://www.nature.com/nbt/collections/compbio/index.html
#cancer #aging #codon_usage
Про ингибиторы деацетилаз.
Quartz: «Scientists have created a drug that replicates the health benefits of exercise» (http://qz.com/783958/scientists-have-created-a-drug-that-replicates-the-health-benefits-of-exercise/)
Original article: «Disruption of the Class IIa HDAC Corepressor
Complex Increases Energy Expenditure and Lipid
Oxidation» (http://www.cell.com/cell-reports/pdf/S2211-1247(16)31051-8.pdf)
Про текущее состояние данных, выкладываемых в публичный доступ.
«Gene name errors are widespread in the scientific literature» (http://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-1044-7)
На самом деле, смешного в этом мало.
Про рак и старение.
«Analysis of cancer genomes reveals basic features of human aging and its role in cancer development» (http://www.nature.com/articles/ncomms12157)
Про codon usage.
«Codon optimality controls differential mRNA translation
during amino acid starvation» (http://rnajournal.cshlp.org/content/early/2016/09/09/rna.058180.116.full.pdf)
«Evolutionary switches between two serine codon sets
are driven by selection» (http://www.pnas.org/content/113/46/13109.full.pdf?with-ds=yes)
Теория эволюции геномов прокариот от Кунина.
«Theory of prokaryotic genome evolution» (http://www.pnas.org/content/113/41/11399.full)
Про антитела против HIV.
The Verge: «One patient’s blood might hold a new weapon against HIV» (http://www.theverge.com/2016/11/17/13670948/hiv-treatment-drug-vaccine-antibodies-neutralizing-blocking)
Original article: «Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth» (http://www.cell.com/immunity/fulltext/S1074-7613(16)30438-1)
Про рибо-переключатели.
«Cotranscriptional folding of a riboswitch at nucleotide resolution» (http://www.nature.com/nsmb/journal/v23/n12/full/nsmb.3316.html)
Про то, как в научных группах используют Slack или MatterMost.
«How scientists use Slack» (http://www.nature.com/news/how-scientists-use-slack-1.21228)
Про Булгакова.
«Maestro, Marguerite, morphine: The last years in the life of Mikhail Bulgakov» (http://www.sciencedirect.com/science/article/pii/S1874391915301743)
Очень странная статья-эссе.
«A Speculative History of DNA: What If Oswald Avery Had Died in 1934?» (http://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.2001197&type=printable)
Обзорная статья про фаговую терапию.
Оригинал на Nautilus: «Will Viruses Save Us From Superbugs?» (http://nautil.us/issue/43/heroes/will-viruses-save-us-from-superbugs)
Перевод на Geektimes: «Спасут ли нас вирусы от супербактерий?»
(https://geektimes.ru/post/283744/)
Про генетику пола.
«Why Sex Is Mostly Binary but Gender Is a Spectrum» (http://nautil.us/issue/43/heroes/why-sex-is-binary-but-gender-is-a-spectrum)
Про неаннотированные splice junctions.
«Human splicing diversity and the extent of unannotated splice junctions across human RNA-seq samples on the Sequence Read Archive» (http://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-1118-6)
Web Collection от Nature: Computational Biology.
http://www.nature.com/nbt/collections/compbio/index.html
#cancer #aging #codon_usage
Quartz
Scientists have created a drug that replicates the health benefits of exercise
Researchers have made the breakthrough of couch potatoes’ dreams.
Некоторые геномы из 2016.
- De novo assembly and phasing of a Korean human genome http://www.nature.com/nature/journal/v538/n7624/pdf/nature20098.pdf
- Evolutionary trajectories of snake genes and genomes revealed by comparative analyses of five-pacer viper http://www.nature.com/articles/ncomms13107.pdf
- The population genomics of rhesus macaques (Macaca mulatta)
based on whole genome sequences http://genome.cshlp.org/content/early/2016/10/17/gr.204255.116.full.pdf
- Comparison of carnivore, omnivore, and herbivore mammalian genomes with a new leopard assembly http://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-1071-4
- The seahorse genome and the evolution of its specialized morphology http://www.nature.com/nature/journal/v540/n7633/full/nature20595.html
#genomes
- De novo assembly and phasing of a Korean human genome http://www.nature.com/nature/journal/v538/n7624/pdf/nature20098.pdf
- Evolutionary trajectories of snake genes and genomes revealed by comparative analyses of five-pacer viper http://www.nature.com/articles/ncomms13107.pdf
- The population genomics of rhesus macaques (Macaca mulatta)
based on whole genome sequences http://genome.cshlp.org/content/early/2016/10/17/gr.204255.116.full.pdf
- Comparison of carnivore, omnivore, and herbivore mammalian genomes with a new leopard assembly http://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-1071-4
- The seahorse genome and the evolution of its specialized morphology http://www.nature.com/nature/journal/v540/n7633/full/nature20595.html
#genomes
Немного neuroscience.
- Dynamic regulation of RNA editing in human brain development and disease http://www.nature.com/neuro/journal/v19/n8/full/nn.4337.html
- High-Throughput Mapping of Single-Neuron Projections by Sequencing of Barcoded RNA http://www.cell.com/neuron/abstract/S0896-6273(16)30421-4?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627316304214%3Fshowall%3Dtrue (обзор в MIT Technology Review https://www.technologyreview.com/s/602203/new-brain-mapping-technique-captures-every-connection-between-neurons/?set=602199&utm_campaign=socialflow&utm_source=twitter&utm_medium=post)
- A brain–spine interface alleviating gait deficits after spinal cord injury in primates http://www.nature.com/nature/journal/v539/n7628/abs/nature20118.html
- The sacral autonomic outflow is sympathetic http://science.sciencemag.org/content/354/6314/893 (обзор от N+1 https://nplus1.ru/material/2016/11/18/it-was-wrong)
- Targeted Intron Retention and Excision for Rapid Gene Regulation in Response to Neuronal Activity (http://www.cell.com/neuron/pdfExtended/S0896-6273(16)30900-X)
#neuroscience
- Dynamic regulation of RNA editing in human brain development and disease http://www.nature.com/neuro/journal/v19/n8/full/nn.4337.html
- High-Throughput Mapping of Single-Neuron Projections by Sequencing of Barcoded RNA http://www.cell.com/neuron/abstract/S0896-6273(16)30421-4?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627316304214%3Fshowall%3Dtrue (обзор в MIT Technology Review https://www.technologyreview.com/s/602203/new-brain-mapping-technique-captures-every-connection-between-neurons/?set=602199&utm_campaign=socialflow&utm_source=twitter&utm_medium=post)
- A brain–spine interface alleviating gait deficits after spinal cord injury in primates http://www.nature.com/nature/journal/v539/n7628/abs/nature20118.html
- The sacral autonomic outflow is sympathetic http://science.sciencemag.org/content/354/6314/893 (обзор от N+1 https://nplus1.ru/material/2016/11/18/it-was-wrong)
- Targeted Intron Retention and Excision for Rapid Gene Regulation in Response to Neuronal Activity (http://www.cell.com/neuron/pdfExtended/S0896-6273(16)30900-X)
#neuroscience
MIT Technology Review
Genetic “barcodes” are helping neuroscientists map the brain circuitry
A new technique called MAP-seq uses RNA bar codes to quickly and cheaply chart connections between brain cells.
Небольшая коллекция обзоров из Nature.
- Transcription–replication conflicts: how they occur and how they are resolved http://www.nature.com/nrm/journal/v17/n9/full/nrm.2016.88.html
- A comparison of tools for the simulation of genomic next-generation sequencing data http://www.nature.com/nrg/journal/v17/n8/abs/nrg.2016.57.html
- Coming of age: ten years of nextgeneration sequencing technologies http://www.nature.com/nrg/journal/v17/n6/full/nrg.2016.49.html
- Small molecules, big targets: drug discovery faces the protein–protein interaction challenge http://www.nature.com/nrd/journal/v15/n8/full/nrd.2016.29.html
- The landscape of DNA methylation amid a perfect storm of autism aetiologies http://www.nature.com/nrn/journal/v17/n7/full/nrn.2016.41.html
#nature_review
- Transcription–replication conflicts: how they occur and how they are resolved http://www.nature.com/nrm/journal/v17/n9/full/nrm.2016.88.html
- A comparison of tools for the simulation of genomic next-generation sequencing data http://www.nature.com/nrg/journal/v17/n8/abs/nrg.2016.57.html
- Coming of age: ten years of nextgeneration sequencing technologies http://www.nature.com/nrg/journal/v17/n6/full/nrg.2016.49.html
- Small molecules, big targets: drug discovery faces the protein–protein interaction challenge http://www.nature.com/nrd/journal/v15/n8/full/nrd.2016.29.html
- The landscape of DNA methylation amid a perfect storm of autism aetiologies http://www.nature.com/nrn/journal/v17/n7/full/nrn.2016.41.html
#nature_review
Nature Reviews Genetics
Coming of age: ten years of next-generation sequencing technologies
Advances in DNA sequencing technologies have led to vast increases in the diversity of sequencing-based applications and in the amount of data generated. This Review discusses the current state-of-the