Подборка про хроматин и эпигенетику.
- Лонгрид в The New Yorker: http://www.newyorker.com/magazine/2016/05/02/breakthroughs-in-epigenetics
- Иллюстрация достижений в эпигенетике от Scientific American: https://blogs.scientificamerican.com/sa-visual/gene-regulation-illustrated/
- Specification and epigenetic programming of the human germ line http://www.nature.com/nrg/journal/v17/n10/full/nrg.2016.88.html
- The detailed 3D multi-loop aggregate/rosette chromatin architecture and functional dynamic organization of the human and mouse genomes https://epigeneticsandchromatin.biomedcentral.com/articles/10.1186/s13072-016-0089-x
- Targeted degradation of CTCF decouples local insulation of chromosome domains from higher‐order genomic compartmentalization http://biorxiv.org/content/biorxiv/early/2016/12/21/095802.full.pdf
#chromatin #epigenetics
- Лонгрид в The New Yorker: http://www.newyorker.com/magazine/2016/05/02/breakthroughs-in-epigenetics
- Иллюстрация достижений в эпигенетике от Scientific American: https://blogs.scientificamerican.com/sa-visual/gene-regulation-illustrated/
- Specification and epigenetic programming of the human germ line http://www.nature.com/nrg/journal/v17/n10/full/nrg.2016.88.html
- The detailed 3D multi-loop aggregate/rosette chromatin architecture and functional dynamic organization of the human and mouse genomes https://epigeneticsandchromatin.biomedcentral.com/articles/10.1186/s13072-016-0089-x
- Targeted degradation of CTCF decouples local insulation of chromosome domains from higher‐order genomic compartmentalization http://biorxiv.org/content/biorxiv/early/2016/12/21/095802.full.pdf
#chromatin #epigenetics
The New Yorker
Same but Different
How the field of epigenetics complicates the nature-versus-nurture debate.
Подборка про длинные некодирующие РНК.
- Pan-Cancer Analyses Reveal Long Intergenic Non-Coding RNAs Relevant to Tumor Diagnosis, Subtyping and Prognosis http://www.sciencedirect.com/science/article/pii/S2352396416301104
- Distinctive Patterns of Transcription and RNA Processing for Human lincRNAs http://www.sciencedirect.com/science/article/pii/S1097276516307742
- Long noncoding RNAs inthe p53 network http://onlinelibrary.wiley.com/wol1/doi/10.1002/wrna.1410/full
- NEAT1 is Required for Survival of Breast Cancer Cells Through FUS and miR-548 http://www.la-press.com/neat1-is-required-for-survival-of-breast-cancer-cells-through-fus-and--article-a5561
- High expression of long non-coding RNA SBF2-AS1 promotes proliferation in non-small cell lung cancer http://jeccr.biomedcentral.com/articles/10.1186/s13046-016-0352-9
- Long Non-coding RNAs in the Cytoplasm (Review) http://www.sciencedirect.com/science/article/pii/S1672022916300377
- Evolution to the rescue: using comparative genomics to understand long non-coding RNAs (Review) http://www.nature.com/nrg/journal/v17/n10/full/nrg.2016.85.html
- Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer http://www.nature.com/ng/journal/v48/n10/full/ng.3637.html
- Local regulation of gene expression by lncRNA promoters, transcription and splicing http://www.nature.com/nature/journal/v539/n7629/full/nature20149.html
- Neighboring Gene Regulation by Antisense Long Non-Coding RNAs http://www.mdpi.com/1422-0067/16/2/3251
- Unusual Processing Generates SPA LncRNAs that Sequester Multiple RNA Binding Proteins http://www.cell.com/molecular-cell/pdfExtended/S1097-2765(16)30630-X
#lncRNAs
- Pan-Cancer Analyses Reveal Long Intergenic Non-Coding RNAs Relevant to Tumor Diagnosis, Subtyping and Prognosis http://www.sciencedirect.com/science/article/pii/S2352396416301104
- Distinctive Patterns of Transcription and RNA Processing for Human lincRNAs http://www.sciencedirect.com/science/article/pii/S1097276516307742
- Long noncoding RNAs inthe p53 network http://onlinelibrary.wiley.com/wol1/doi/10.1002/wrna.1410/full
- NEAT1 is Required for Survival of Breast Cancer Cells Through FUS and miR-548 http://www.la-press.com/neat1-is-required-for-survival-of-breast-cancer-cells-through-fus-and--article-a5561
- High expression of long non-coding RNA SBF2-AS1 promotes proliferation in non-small cell lung cancer http://jeccr.biomedcentral.com/articles/10.1186/s13046-016-0352-9
- Long Non-coding RNAs in the Cytoplasm (Review) http://www.sciencedirect.com/science/article/pii/S1672022916300377
- Evolution to the rescue: using comparative genomics to understand long non-coding RNAs (Review) http://www.nature.com/nrg/journal/v17/n10/full/nrg.2016.85.html
- Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer http://www.nature.com/ng/journal/v48/n10/full/ng.3637.html
- Local regulation of gene expression by lncRNA promoters, transcription and splicing http://www.nature.com/nature/journal/v539/n7629/full/nature20149.html
- Neighboring Gene Regulation by Antisense Long Non-Coding RNAs http://www.mdpi.com/1422-0067/16/2/3251
- Unusual Processing Generates SPA LncRNAs that Sequester Multiple RNA Binding Proteins http://www.cell.com/molecular-cell/pdfExtended/S1097-2765(16)30630-X
#lncRNAs
La-Press
NEAT1 is Required for Survival of Breast Cancer Cells Through FUS and
NEAT1 is Required for Survival of Breast Cancer Cells Through FUS and miR-548
Подборка материалов на разные темы.
Про ингибиторы деацетилаз.
Quartz: «Scientists have created a drug that replicates the health benefits of exercise» (http://qz.com/783958/scientists-have-created-a-drug-that-replicates-the-health-benefits-of-exercise/)
Original article: «Disruption of the Class IIa HDAC Corepressor
Complex Increases Energy Expenditure and Lipid
Oxidation» (http://www.cell.com/cell-reports/pdf/S2211-1247(16)31051-8.pdf)
Про текущее состояние данных, выкладываемых в публичный доступ.
«Gene name errors are widespread in the scientific literature» (http://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-1044-7)
На самом деле, смешного в этом мало.
Про рак и старение.
«Analysis of cancer genomes reveals basic features of human aging and its role in cancer development» (http://www.nature.com/articles/ncomms12157)
Про codon usage.
«Codon optimality controls differential mRNA translation
during amino acid starvation» (http://rnajournal.cshlp.org/content/early/2016/09/09/rna.058180.116.full.pdf)
«Evolutionary switches between two serine codon sets
are driven by selection» (http://www.pnas.org/content/113/46/13109.full.pdf?with-ds=yes)
Теория эволюции геномов прокариот от Кунина.
«Theory of prokaryotic genome evolution» (http://www.pnas.org/content/113/41/11399.full)
Про антитела против HIV.
The Verge: «One patient’s blood might hold a new weapon against HIV» (http://www.theverge.com/2016/11/17/13670948/hiv-treatment-drug-vaccine-antibodies-neutralizing-blocking)
Original article: «Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth» (http://www.cell.com/immunity/fulltext/S1074-7613(16)30438-1)
Про рибо-переключатели.
«Cotranscriptional folding of a riboswitch at nucleotide resolution» (http://www.nature.com/nsmb/journal/v23/n12/full/nsmb.3316.html)
Про то, как в научных группах используют Slack или MatterMost.
«How scientists use Slack» (http://www.nature.com/news/how-scientists-use-slack-1.21228)
Про Булгакова.
«Maestro, Marguerite, morphine: The last years in the life of Mikhail Bulgakov» (http://www.sciencedirect.com/science/article/pii/S1874391915301743)
Очень странная статья-эссе.
«A Speculative History of DNA: What If Oswald Avery Had Died in 1934?» (http://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.2001197&type=printable)
Обзорная статья про фаговую терапию.
Оригинал на Nautilus: «Will Viruses Save Us From Superbugs?» (http://nautil.us/issue/43/heroes/will-viruses-save-us-from-superbugs)
Перевод на Geektimes: «Спасут ли нас вирусы от супербактерий?»
(https://geektimes.ru/post/283744/)
Про генетику пола.
«Why Sex Is Mostly Binary but Gender Is a Spectrum» (http://nautil.us/issue/43/heroes/why-sex-is-binary-but-gender-is-a-spectrum)
Про неаннотированные splice junctions.
«Human splicing diversity and the extent of unannotated splice junctions across human RNA-seq samples on the Sequence Read Archive» (http://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-1118-6)
Web Collection от Nature: Computational Biology.
http://www.nature.com/nbt/collections/compbio/index.html
#cancer #aging #codon_usage
Про ингибиторы деацетилаз.
Quartz: «Scientists have created a drug that replicates the health benefits of exercise» (http://qz.com/783958/scientists-have-created-a-drug-that-replicates-the-health-benefits-of-exercise/)
Original article: «Disruption of the Class IIa HDAC Corepressor
Complex Increases Energy Expenditure and Lipid
Oxidation» (http://www.cell.com/cell-reports/pdf/S2211-1247(16)31051-8.pdf)
Про текущее состояние данных, выкладываемых в публичный доступ.
«Gene name errors are widespread in the scientific literature» (http://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-1044-7)
На самом деле, смешного в этом мало.
Про рак и старение.
«Analysis of cancer genomes reveals basic features of human aging and its role in cancer development» (http://www.nature.com/articles/ncomms12157)
Про codon usage.
«Codon optimality controls differential mRNA translation
during amino acid starvation» (http://rnajournal.cshlp.org/content/early/2016/09/09/rna.058180.116.full.pdf)
«Evolutionary switches between two serine codon sets
are driven by selection» (http://www.pnas.org/content/113/46/13109.full.pdf?with-ds=yes)
Теория эволюции геномов прокариот от Кунина.
«Theory of prokaryotic genome evolution» (http://www.pnas.org/content/113/41/11399.full)
Про антитела против HIV.
The Verge: «One patient’s blood might hold a new weapon against HIV» (http://www.theverge.com/2016/11/17/13670948/hiv-treatment-drug-vaccine-antibodies-neutralizing-blocking)
Original article: «Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth» (http://www.cell.com/immunity/fulltext/S1074-7613(16)30438-1)
Про рибо-переключатели.
«Cotranscriptional folding of a riboswitch at nucleotide resolution» (http://www.nature.com/nsmb/journal/v23/n12/full/nsmb.3316.html)
Про то, как в научных группах используют Slack или MatterMost.
«How scientists use Slack» (http://www.nature.com/news/how-scientists-use-slack-1.21228)
Про Булгакова.
«Maestro, Marguerite, morphine: The last years in the life of Mikhail Bulgakov» (http://www.sciencedirect.com/science/article/pii/S1874391915301743)
Очень странная статья-эссе.
«A Speculative History of DNA: What If Oswald Avery Had Died in 1934?» (http://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.2001197&type=printable)
Обзорная статья про фаговую терапию.
Оригинал на Nautilus: «Will Viruses Save Us From Superbugs?» (http://nautil.us/issue/43/heroes/will-viruses-save-us-from-superbugs)
Перевод на Geektimes: «Спасут ли нас вирусы от супербактерий?»
(https://geektimes.ru/post/283744/)
Про генетику пола.
«Why Sex Is Mostly Binary but Gender Is a Spectrum» (http://nautil.us/issue/43/heroes/why-sex-is-binary-but-gender-is-a-spectrum)
Про неаннотированные splice junctions.
«Human splicing diversity and the extent of unannotated splice junctions across human RNA-seq samples on the Sequence Read Archive» (http://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-1118-6)
Web Collection от Nature: Computational Biology.
http://www.nature.com/nbt/collections/compbio/index.html
#cancer #aging #codon_usage
Quartz
Scientists have created a drug that replicates the health benefits of exercise
Researchers have made the breakthrough of couch potatoes’ dreams.
Некоторые геномы из 2016.
- De novo assembly and phasing of a Korean human genome http://www.nature.com/nature/journal/v538/n7624/pdf/nature20098.pdf
- Evolutionary trajectories of snake genes and genomes revealed by comparative analyses of five-pacer viper http://www.nature.com/articles/ncomms13107.pdf
- The population genomics of rhesus macaques (Macaca mulatta)
based on whole genome sequences http://genome.cshlp.org/content/early/2016/10/17/gr.204255.116.full.pdf
- Comparison of carnivore, omnivore, and herbivore mammalian genomes with a new leopard assembly http://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-1071-4
- The seahorse genome and the evolution of its specialized morphology http://www.nature.com/nature/journal/v540/n7633/full/nature20595.html
#genomes
- De novo assembly and phasing of a Korean human genome http://www.nature.com/nature/journal/v538/n7624/pdf/nature20098.pdf
- Evolutionary trajectories of snake genes and genomes revealed by comparative analyses of five-pacer viper http://www.nature.com/articles/ncomms13107.pdf
- The population genomics of rhesus macaques (Macaca mulatta)
based on whole genome sequences http://genome.cshlp.org/content/early/2016/10/17/gr.204255.116.full.pdf
- Comparison of carnivore, omnivore, and herbivore mammalian genomes with a new leopard assembly http://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-1071-4
- The seahorse genome and the evolution of its specialized morphology http://www.nature.com/nature/journal/v540/n7633/full/nature20595.html
#genomes
Немного neuroscience.
- Dynamic regulation of RNA editing in human brain development and disease http://www.nature.com/neuro/journal/v19/n8/full/nn.4337.html
- High-Throughput Mapping of Single-Neuron Projections by Sequencing of Barcoded RNA http://www.cell.com/neuron/abstract/S0896-6273(16)30421-4?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627316304214%3Fshowall%3Dtrue (обзор в MIT Technology Review https://www.technologyreview.com/s/602203/new-brain-mapping-technique-captures-every-connection-between-neurons/?set=602199&utm_campaign=socialflow&utm_source=twitter&utm_medium=post)
- A brain–spine interface alleviating gait deficits after spinal cord injury in primates http://www.nature.com/nature/journal/v539/n7628/abs/nature20118.html
- The sacral autonomic outflow is sympathetic http://science.sciencemag.org/content/354/6314/893 (обзор от N+1 https://nplus1.ru/material/2016/11/18/it-was-wrong)
- Targeted Intron Retention and Excision for Rapid Gene Regulation in Response to Neuronal Activity (http://www.cell.com/neuron/pdfExtended/S0896-6273(16)30900-X)
#neuroscience
- Dynamic regulation of RNA editing in human brain development and disease http://www.nature.com/neuro/journal/v19/n8/full/nn.4337.html
- High-Throughput Mapping of Single-Neuron Projections by Sequencing of Barcoded RNA http://www.cell.com/neuron/abstract/S0896-6273(16)30421-4?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627316304214%3Fshowall%3Dtrue (обзор в MIT Technology Review https://www.technologyreview.com/s/602203/new-brain-mapping-technique-captures-every-connection-between-neurons/?set=602199&utm_campaign=socialflow&utm_source=twitter&utm_medium=post)
- A brain–spine interface alleviating gait deficits after spinal cord injury in primates http://www.nature.com/nature/journal/v539/n7628/abs/nature20118.html
- The sacral autonomic outflow is sympathetic http://science.sciencemag.org/content/354/6314/893 (обзор от N+1 https://nplus1.ru/material/2016/11/18/it-was-wrong)
- Targeted Intron Retention and Excision for Rapid Gene Regulation in Response to Neuronal Activity (http://www.cell.com/neuron/pdfExtended/S0896-6273(16)30900-X)
#neuroscience
MIT Technology Review
Genetic “barcodes” are helping neuroscientists map the brain circuitry
A new technique called MAP-seq uses RNA bar codes to quickly and cheaply chart connections between brain cells.
Небольшая коллекция обзоров из Nature.
- Transcription–replication conflicts: how they occur and how they are resolved http://www.nature.com/nrm/journal/v17/n9/full/nrm.2016.88.html
- A comparison of tools for the simulation of genomic next-generation sequencing data http://www.nature.com/nrg/journal/v17/n8/abs/nrg.2016.57.html
- Coming of age: ten years of nextgeneration sequencing technologies http://www.nature.com/nrg/journal/v17/n6/full/nrg.2016.49.html
- Small molecules, big targets: drug discovery faces the protein–protein interaction challenge http://www.nature.com/nrd/journal/v15/n8/full/nrd.2016.29.html
- The landscape of DNA methylation amid a perfect storm of autism aetiologies http://www.nature.com/nrn/journal/v17/n7/full/nrn.2016.41.html
#nature_review
- Transcription–replication conflicts: how they occur and how they are resolved http://www.nature.com/nrm/journal/v17/n9/full/nrm.2016.88.html
- A comparison of tools for the simulation of genomic next-generation sequencing data http://www.nature.com/nrg/journal/v17/n8/abs/nrg.2016.57.html
- Coming of age: ten years of nextgeneration sequencing technologies http://www.nature.com/nrg/journal/v17/n6/full/nrg.2016.49.html
- Small molecules, big targets: drug discovery faces the protein–protein interaction challenge http://www.nature.com/nrd/journal/v15/n8/full/nrd.2016.29.html
- The landscape of DNA methylation amid a perfect storm of autism aetiologies http://www.nature.com/nrn/journal/v17/n7/full/nrn.2016.41.html
#nature_review
Nature Reviews Genetics
Coming of age: ten years of next-generation sequencing technologies
Advances in DNA sequencing technologies have led to vast increases in the diversity of sequencing-based applications and in the amount of data generated. This Review discusses the current state-of-the
В дополнение к статьям про хроматин.
A genome-wide map of chromatin conformation in human cells at the 1–3 nucleosome (50–500 bp) scale is reported
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature20781.html
A genome-wide map of chromatin conformation in human cells at the 1–3 nucleosome (50–500 bp) scale is reported
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature20781.html
И про длинные некодирующие РНК в Science.
CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells
http://science.sciencemag.org/content/early/2016/12/14/science.aah7111
CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells
http://science.sciencemag.org/content/early/2016/12/14/science.aah7111
Science
CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells
The human genome produces thousands of long noncoding RNAs (lncRNAs) – transcripts >200 nucleotides long that do not encode proteins. While critical roles in normal biology and disease have been revealed for a subset of lncRNAs, the function of the vast majority…
The New York Times, как обычно, радует своей колонкой про науку.
- Некролог, посвященный Питеру Ноуэлу. https://www.nytimes.com/2017/01/11/science/dr-peter-nowell-who-helped-transform-cancer-research-dies-at-88.html
- Огромная статья про неандертальцев. https://www.nytimes.com/2017/01/11/magazine/neanderthals-were-people-too.html
- Про древних беспозвоночных. https://www.nytimes.com/2017/01/11/science/hyolith-fossil.html
- Статья на очень современную тему — про ТАДы. И почему это важно в контексте заболеваний. https://www.nytimes.com/2017/01/09/science/dna-tads.html
Статья отличная, хотя и написана по мотивам не самых новых статей в Nature (http://www.nature.com/nature/journal/v538/n7624/full/nature19800.html) и Cell (http://www.cell.com/cell/abstract/S0092-8674(15)00377-3).
- Некролог, посвященный Питеру Ноуэлу. https://www.nytimes.com/2017/01/11/science/dr-peter-nowell-who-helped-transform-cancer-research-dies-at-88.html
- Огромная статья про неандертальцев. https://www.nytimes.com/2017/01/11/magazine/neanderthals-were-people-too.html
- Про древних беспозвоночных. https://www.nytimes.com/2017/01/11/science/hyolith-fossil.html
- Статья на очень современную тему — про ТАДы. И почему это важно в контексте заболеваний. https://www.nytimes.com/2017/01/09/science/dna-tads.html
Статья отличная, хотя и написана по мотивам не самых новых статей в Nature (http://www.nature.com/nature/journal/v538/n7624/full/nature19800.html) и Cell (http://www.cell.com/cell/abstract/S0092-8674(15)00377-3).
NY Times
Dr. Peter Nowell, Who Helped Transform Cancer Research, Dies at 88 (Published 2017)
Dr. Nowell and a colleague discovered the first genetic defect proven to cause cancer, which led to major advances by other scientists decades later.
Геном бобра.
http://www.g3journal.org/content/early/2017/01/13/g3.116.038208.1.abstract
Напоминание из 2007 о том, что синонимические замены могут иметь заметные последствия. В данном случае, например, замены влияют на сплайсинг.
http://www.mgmjournal.com/article/S1096-7192(07)00439-8/abstract
Снова про осьминогов. Теперь заметка от The Washington Post.
https://www.washingtonpost.com/opinions/just-how-smart-is-an-octopus/2017/01/06/a2f1ed22-acd0-11e6-8b45-f8e493f06fcd_story.html?utm_term=.04e6b4ef91eb
Говорят, геном за 100$ не за горами. (На самом деле до этого ещё далеко.)
https://www.statnews.com/2017/01/09/illumina-ushering-in-the-100-genome/
Nature Review про эпигенетику.
http://www.nature.com/nrg/journal/v18/n1/pdf/nrg.2016.138.pdf
2017 только начался, а уже снова пишут про старение.
http://onlinelibrary.wiley.com/doi/10.1111/acel.12557/full
Про репарацию ДНК в контексте нейродегенеративных заболеваний.
http://www.nature.com/nature/journal/v541/n7635/full/nature21107.html
http://www.nature.com/nature/journal/v541/n7635/full/nature20790.html
Взгляд на РНК из 2017.
«Functional RNA classes: a matter of time?»
http://www.nature.com/nsmb/journal/v24/n1/full/nsmb.3354.html
«Mining ancient proteins for next-generation drugs», Nature Biotechnology.
http://www.nature.com/nbt/journal/v35/n1/full/nbt.3762.html
«Genome-wide mapping of mutations at single-nucleotide resolution for protein, metabolic and genome engineering», Nature Biotechnology
http://www.nature.com/nbt/journal/v35/n1/full/nbt.3718.html
http://www.g3journal.org/content/early/2017/01/13/g3.116.038208.1.abstract
Напоминание из 2007 о том, что синонимические замены могут иметь заметные последствия. В данном случае, например, замены влияют на сплайсинг.
http://www.mgmjournal.com/article/S1096-7192(07)00439-8/abstract
Снова про осьминогов. Теперь заметка от The Washington Post.
https://www.washingtonpost.com/opinions/just-how-smart-is-an-octopus/2017/01/06/a2f1ed22-acd0-11e6-8b45-f8e493f06fcd_story.html?utm_term=.04e6b4ef91eb
Говорят, геном за 100$ не за горами. (На самом деле до этого ещё далеко.)
https://www.statnews.com/2017/01/09/illumina-ushering-in-the-100-genome/
Nature Review про эпигенетику.
http://www.nature.com/nrg/journal/v18/n1/pdf/nrg.2016.138.pdf
2017 только начался, а уже снова пишут про старение.
http://onlinelibrary.wiley.com/doi/10.1111/acel.12557/full
Про репарацию ДНК в контексте нейродегенеративных заболеваний.
http://www.nature.com/nature/journal/v541/n7635/full/nature21107.html
http://www.nature.com/nature/journal/v541/n7635/full/nature20790.html
Взгляд на РНК из 2017.
«Functional RNA classes: a matter of time?»
http://www.nature.com/nsmb/journal/v24/n1/full/nsmb.3354.html
«Mining ancient proteins for next-generation drugs», Nature Biotechnology.
http://www.nature.com/nbt/journal/v35/n1/full/nbt.3762.html
«Genome-wide mapping of mutations at single-nucleotide resolution for protein, metabolic and genome engineering», Nature Biotechnology
http://www.nature.com/nbt/journal/v35/n1/full/nbt.3718.html
Отличная история о клювах птиц, опубликованная в Nature.
Статья в The New York Times: https://www.nytimes.com/2017/02/01/science/birds-beaks-evolution.html
Краткий обзор: http://www.nature.com/nature/journal/vaop/ncurrent/full/nature21494.html
Оригинальная статья: http://www.nature.com/nature/journal/vaop/ncurrent/full/nature21074.html
Статья в The New York Times: https://www.nytimes.com/2017/02/01/science/birds-beaks-evolution.html
Краткий обзор: http://www.nature.com/nature/journal/vaop/ncurrent/full/nature21494.html
Оригинальная статья: http://www.nature.com/nature/journal/vaop/ncurrent/full/nature21074.html
Nytimes
Finding the Speed of Evolution in a Study of Bird Beaks
Much of the variety in the bills of today’s birds evolved long ago, very quickly, a study found, yet bill evolution didn’t slow down over time.
Циркадные ритмы + deep sequencing.
Кажется, CLOCK-гены — одна из тех тем, которые будут активно развиваться в ближайшие годы, в т. ч. с применением технологий NGS, и которые преподнесут немало нового и неожиданного.
http://www.nature.com/articles/ncomms14529
Кажется, CLOCK-гены — одна из тех тем, которые будут активно развиваться в ближайшие годы, в т. ч. с применением технологий NGS, и которые преподнесут немало нового и неожиданного.
http://www.nature.com/articles/ncomms14529
Nature
Circadian deep sequencing reveals stress-response genes that adopt robust rhythmic expression during aging
Nature Communications - Disruption of circadian rhythms leads to reduced healthspan, but the mechanisms by which the normal clock protects aging organisms are not known. Here, the authors show that...
А квантовые компьютеры уже используют в биоинформатике.
https://www.dwavesys.com/press-releases/d-wave-initiates-open-quantum-software-environment
https://www.dwavesys.com/press-releases/d-wave-initiates-open-quantum-software-environment
Подборка разных материалов за последнее время.
- Очередная статья про ТАДы и пространственную организацию генома. http://biorxiv.org/content/early/2017/03/08/115063
- Генная терапия способна лечить серповидно-клеточную анемию. http://www.nejm.org/doi/10.1056/NEJMoa1609677
- Про диету и продолжительность жизни. http://advances.sciencemag.org/content/3/2/e1601833
- Крутая статья из Neuron с видео-абстрактом. Про аллель-специфичную экспрессию в мозге. http://www.cell.com/neuron/fulltext/S0896-6273(17)30057-0
- Ещё одна методика секвенирования 3'-концов транскриптов. http://biorxiv.org/content/early/2017/02/24/109272
- Милая заметка от CSHL про статью (http://www.cell.com/neuron/abstract/S0896-6273(16)30844-3) с рисунками «от руки». http://labdish.cshl.edu/2017/03/01/new-art-supplies-for-visualizing-tiny-machines-in-the-brain/
- Очередная статья про ТАДы и пространственную организацию генома. http://biorxiv.org/content/early/2017/03/08/115063
- Генная терапия способна лечить серповидно-клеточную анемию. http://www.nejm.org/doi/10.1056/NEJMoa1609677
- Про диету и продолжительность жизни. http://advances.sciencemag.org/content/3/2/e1601833
- Крутая статья из Neuron с видео-абстрактом. Про аллель-специфичную экспрессию в мозге. http://www.cell.com/neuron/fulltext/S0896-6273(17)30057-0
- Ещё одна методика секвенирования 3'-концов транскриптов. http://biorxiv.org/content/early/2017/02/24/109272
- Милая заметка от CSHL про статью (http://www.cell.com/neuron/abstract/S0896-6273(16)30844-3) с рисунками «от руки». http://labdish.cshl.edu/2017/03/01/new-art-supplies-for-visualizing-tiny-machines-in-the-brain/
bioRxiv
High-resolution TADs reveal DNA sequences underlying genome organization in flies
Eukaryotic chromatin is partitioned into domains called TADs that are broadly conserved between species and virtually identical among cell types within the same species. Previous studies in mammals have shown that the DNA binding protein CTCF and cohesin…
И такой вот набор Nature News про эпигенетику.
- An epigenetics gold rush: new controls for gene expression http://www.nature.com/news/an-epigenetics-gold-rush-new-controls-for-gene-expression-1.21513
- Poverty linked to epigenetic changes and mental illness http://www.nature.com/news/poverty-linked-to-epigenetic-changes-and-mental-illness-1.19972
- Epigenomics starts to make its mark http://www.nature.com/news/epigenomics-starts-to-make-its-mark-1.14973
- Behaviour and biology: The accidental epigeneticisthttp://www.nature.com/news/behaviour-and-biology-the-accidental-epigeneticist-1.14441
- An epigenetics gold rush: new controls for gene expression http://www.nature.com/news/an-epigenetics-gold-rush-new-controls-for-gene-expression-1.21513
- Poverty linked to epigenetic changes and mental illness http://www.nature.com/news/poverty-linked-to-epigenetic-changes-and-mental-illness-1.19972
- Epigenomics starts to make its mark http://www.nature.com/news/epigenomics-starts-to-make-its-mark-1.14973
- Behaviour and biology: The accidental epigeneticisthttp://www.nature.com/news/behaviour-and-biology-the-accidental-epigeneticist-1.14441
Nature News & Comment
An epigenetics gold rush: new controls for gene expression
How rediscovered chemical tags on DNA and RNA are shaking up the field.
Про то, как связано взаимодействие FOXO4 и p53 со старением.
http://www.cell.com/cell/fulltext/S0092-8674(17)30246-5
#aging
http://www.cell.com/cell/fulltext/S0092-8674(17)30246-5
#aging
и тебя отсеквенируем
Циркадные ритмы + deep sequencing. Кажется, CLOCK-гены — одна из тех тем, которые будут активно развиваться в ближайшие годы, в т. ч. с применением технологий NGS, и которые преподнесут немало нового и неожиданного. http://www.nature.com/articles/ncomms14529
И снова про циркадные ритмы!
http://www.cell.com/cell/fulltext/S0092-8674(17)30346-X
https://www.reddit.com/r/science/comments/646hoo/some_people_may_stay_up_late_and_have_trouble/
#circadian
http://www.cell.com/cell/fulltext/S0092-8674(17)30346-X
https://www.reddit.com/r/science/comments/646hoo/some_people_may_stay_up_late_and_have_trouble/
#circadian
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