Подборка материалов на разные темы.

Про ингибиторы деацетилаз.
Quartz: «Scientists have created a drug that replicates the health benefits of exercise» (http://qz.com/783958/scientists-have-created-a-drug-that-replicates-the-health-benefits-of-exercise/)
Original article: «Disruption of the Class IIa HDAC Corepressor
Complex Increases Energy Expenditure and Lipid
Oxidation» (http://www.cell.com/cell-reports/pdf/S2211-1247(16)31051-8.pdf)

Про текущее состояние данных, выкладываемых в публичный доступ.
«Gene name errors are widespread in the scientific literature» (http://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-1044-7)
На самом деле, смешного в этом мало.

Про рак и старение.
«Analysis of cancer genomes reveals basic features of human aging and its role in cancer development» (http://www.nature.com/articles/ncomms12157)

Про codon usage.
«Codon optimality controls differential mRNA translation
during amino acid starvation» (http://rnajournal.cshlp.org/content/early/2016/09/09/rna.058180.116.full.pdf)
«Evolutionary switches between two serine codon sets
are driven by selection» (http://www.pnas.org/content/113/46/13109.full.pdf?with-ds=yes)

Теория эволюции геномов прокариот от Кунина.
«Theory of prokaryotic genome evolution» (http://www.pnas.org/content/113/41/11399.full)

Про антитела против HIV.
The Verge: «One patient’s blood might hold a new weapon against HIV» (http://www.theverge.com/2016/11/17/13670948/hiv-treatment-drug-vaccine-antibodies-neutralizing-blocking)
Original article: «Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth» (http://www.cell.com/immunity/fulltext/S1074-7613(16)30438-1)

Про рибо-переключатели.
«Cotranscriptional folding of a riboswitch at nucleotide resolution» (http://www.nature.com/nsmb/journal/v23/n12/full/nsmb.3316.html)

Про то, как в научных группах используют Slack или MatterMost.
«How scientists use Slack» (http://www.nature.com/news/how-scientists-use-slack-1.21228)

Про Булгакова.
«Maestro, Marguerite, morphine: The last years in the life of Mikhail Bulgakov» (http://www.sciencedirect.com/science/article/pii/S1874391915301743)

Очень странная статья-эссе.
«A Speculative History of DNA: What If Oswald Avery Had Died in 1934?» (http://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.2001197&type=printable)

Обзорная статья про фаговую терапию.
Оригинал на Nautilus: «Will Viruses Save Us From Superbugs?» (http://nautil.us/issue/43/heroes/will-viruses-save-us-from-superbugs)
Перевод на Geektimes: «Спасут ли нас вирусы от супербактерий?»
(https://geektimes.ru/post/283744/)

Про генетику пола.
«Why Sex Is Mostly Binary but Gender Is a Spectrum» (http://nautil.us/issue/43/heroes/why-sex-is-binary-but-gender-is-a-spectrum)

Про неаннотированные splice junctions.
«Human splicing diversity and the extent of unannotated splice junctions across human RNA-seq samples on the Sequence Read Archive» (http://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-1118-6)

Web Collection от Nature: Computational Biology.
http://www.nature.com/nbt/collections/compbio/index.html

#cancer #aging #codon_usage

​​Weakly supervised mitosis detection in breast histopathology images using concentric loss

Weakly-supervised mitosis detection in breast histopathology images shows that only using one-click annotation can obtain the best performances on three challenging datasets.

Link: https://www.sciencedirect.com/science/article/abs/pii/S1361841519300118?dgcid=author

#healthcare #medical #CV #cancer #DL